Zopiclone was first developed and introduced in 1986 by Rhône-Poulenc SA, now
part of Sanofi-Aventis , the main worldwide manufacturer of the drug. Originally
it was promoted as being an improvement on benzodiazepines .
Zopiclone, as traditionally sold worldwide, is a racemic mixture of two
stereoisomers , only one of which is active. In 2005, the pharmaceutical
company Sepracor of Marlborough, Massachusetts began marketing the active
stereoisomer eszopiclone under the
name Lunesta in the United
States .
Zopiclone is already available off-patent in a number of European countries as well as Brazil and Canada . The es
zopiclone and zopiclone
difference is in the dose—the strongest es
zopiclone derivative dosage contains 3 mg of the therapeutic stereoisomer, whereas, the
highest
zopiclone dosage (7.5 mg)
contains 3.75 mg of the active stereoisomer.
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